Single Embryo Transfer and CCS in patients under 35
Our very own Dr. Ursula Balthazar has published a study on Elective Single Embryo Transfer(SET) with Comprehensive Chromosome Screening(CCS) versus SET without CCS in patients under the age of 35.
A recent study by Reproductive Medicine Associates of Texas compared pregnancy rates of elective single embryo transfer with comprehensive chromosomal screening (CCS) in IVF patients 35 and under, compared to patients in the same age group who did elective single embryo transfer without CCS. The researchers concluded, “For the small percentage of cases that fit the criteria of having embryos available for transfer as well as cryopreservation, elective single embryo transfer without the additional cost of CCS may prove equally if not more beneficial.”
CCS is a type of preimplantation genetic screening (PGS), genetic testing that evaluates all 23 pairs of chromosomes in an embryo created in an IVF cycle. A “euploid” embryo has a correct number of chromosomes; an “aneuploid” embryo has an incorrect number of chromosomes.
A patient’s age and the number of embryos they create will give you a relative prognosis for the percent of embryos that is going to be euploid, says Dr. Ursula Balthazar, a fertility doctor with Reproductive Medicine Associates of Texas. In patients who are under 35 and have more than three embryos it is expected that at least half will be genetically normal. “So it makes sense that the implantation rate of those two patient populations is the same, but an impactful thing to have shown,” Balthazar says.